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Erap1 and PDE8A are downregulated in cattle protected against bovine tuberculosis

Colaborador(es): Blanco, Federico C. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología (CICVyA). Buenos Aires, Argentina | Soria, Marcelo Abel. Universidad de Buenos Aires. Facultad de Agronomía. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales (INBA). Buenos Aires, Argentina. CONICET – Universidad de Buenos Aires. Instituto de Investigaciones en Biociencias Agrícolas y Ambientales (INBA). Buenos Aires, Argentina | Klepp, Laura Inés. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología (CICVyA). Buenos Aires, Argentina | Bigi, Fabiana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología (CICVyA). Buenos Aires, Argentina.
ISSN: 1464-1801.Tipo de material: Artículos y capítulos. Recurso electrónico.Tema(s): MYCOBACTERIUM BOVIS | TRANSCRIPTOMICS | CATTLE | IMMUNE RESPONSE | Recursos en línea: Haga clic para acceso en línea | LINK AL EDITOR En: Journal of Molecular Microbiology and Biotechnology Vol.27, no.4 (2017), p.237-245, tbls., grafs.Resumen: Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.
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Bovine tuberculosis (bTB) is a zoonotic disease caused by Mycobacterium bovis that is responsible for significant economic losses worldwide. In spite of its relevance, the limited knowledge about the host immune responses that provide effective protection against the disease has long hampered the development of an effective vaccine. The identification of host proteins with an expression that correlates with protection against bTB would contribute to the understanding of the cattle defence mechanisms against M. bovis infection. In this study, we found that ERAP1 and PDE8A were downregulated in vaccinated cattle that were protected from experimental M. bovis challenge. Remarkably, both genes encode proteins that have been negatively associated with immune protection against bTB.

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